A SMALL-MOLECULE APPROACH TO RESTORE FEMALE STERILITY PHENOTYPE TARGETED BY A HOMING SUPPRESSION GENE DRIVE IN THE FRUIT PEST DROSOPHILA SUZUKII.

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.

CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests.A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles.One approach to mitigate the development of resistance involves targeting functionally constrained regions using multiple gR

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Safety and Efficacy of Oral Melatonin When Combined with Thoracic Epidural Analgesia in Patients with Bilateral Multiple Fracture Ribs

Ahmed M Fetouh Abdelrahman,1 Amany Faheem Abdel Salam Omara,1 Alaa Ali M Elzohry2 1Anesthesia and Surgical ICU, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, EgyptCorrespondence: Alaa Ali M ElzohryDepartment of Anesthesia, ICU and Pain Re

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Identification of PPARG as key gene to link coronary atherosclerosis disease and rheumatoid arthritis via microarray data analysis.

BackgroundInflammation is the common pathogenesis of coronary atherosclerosis disease (CAD) and rheumatoid arthritis (RA).Although it is established that RA increases the risk of CAD, the underlining mechanism remained indefinite.This study seeks to explore the molecular mechanisms of RA linked CAD and identify potential target gene for early predi

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